Levofloxacin-Dexlansoprazole Based Quadruple Therapy for Helicobacter Pylori Eradication in Thailand
نویسندگان
چکیده
Helicobacter pylori (H. pylori), a gram-negative bacterium found on the luminal surface of the gastric epithelium, was first isolated in 1984 (Marshall and Warren, 1984). It induces chronic inflammation of the underlying mucosa resulting in the development of important upper gastrointestinal diseases such as gastritis, peptic ulcer diseases, mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric cancer (Rauws and Tytgat, 1990; Parsonnet et al., 1991; Bayerdorffer et al., 1995; Vilaichone and Mahachai, 2001). Moreover, a recent meta-analysis has shown that H. pylori eradication potentially reduces the incidence of gastric cancer, especially in high prevalence area of gastric cancer (Ford et al., 2014).
منابع مشابه
Comparing Clarithromycin- and Levofloxacin-Containing Triple Therapies for First Line Helicobacter pylori Eradication in Mazandran Province, Iran
Background and purpose: About half of the world’s population is infected with Helicobacter pylori (H. pylori). But, the efficacy of therapeutic regimens decreases over time due to increasing resistance of H. pylori to antibiotics. This research aimed at evaluating the efficacy of two triple therapy regimens. Materials and methods: This tudy was performed in Sari Imam Khomeini Hospital, 2016...
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BACKGROUND The aim of the present open-label, randomized control trial was to determine the clinical efficacy and safety of two 1-week bismuth-containing quadruple regimens and 1 levofloxacin-based triple regimen for the eradication of Helicobacter pylori infection in treatment-naive patients. The influence of susceptibility and host CYP2C19 polymorphisms on the efficacy was also evaluated. M...
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Helicobacter pylori (H. Pylori) infection is currently recognized as the major cause of chronic active gastritis, peptic ulcer disease and mucosa associated lymphoid tissue (MALT) lymphoma and carcinoma of the stomach. Eradication of the infection will prevent the recurrence of the majority of such diseases. Different combined treatments have been tried in Iran for eradication of H. Pylori, but...
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